Preclinical female model of urogenital dysfunction and pathophysiological changes after pelvic radiation therapy

HIGHLIGHTS

• What: This study characterized the impact of pelvic RT at early and late timepoints on female rat bladder, vaginal, and urethral physiology and morphology. The authors demonstrate changes in vaginal blood flow, urogenital smooth and skeletal musculature, and vaginal inflammation in both acute and chronic phases using a female rat model of pelvic RT. This study demonstrated that neurotransmitter-mediated detrusor contractions decrease acutely following pelvic RT. The authors evaluated injury following a single 20 Gy dose of pelvic RT.
• Who: Dysfunction and colleagues from the Department of Physiology, Brody School of Medicine, East Carolina . . .
  

   

  

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