Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria

HIGHLIGHTS

• who: Luciana S. Salaverry from the Biochemistry, University of Buenos Aires (UBA), Buenos Aires, Argentina Laboratory of Immunotoxicology (LaITo), IDEHU‑CONICET have published the research: Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria, in the Journal: (JOURNAL)
• what: The aim of this work was to expose BC-K562 cells to conditions of hypoxia ( and amp;lt; 1% ­O2) to force a metabolic change, and explore the cytotoxic effect of the six above-mentioned drugs that target mitochondria, or mitochondriarelated cell stress responses (MRCSR) such . . .
  

   

  

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