HIGHLIGHTS
- What: This work demonstrated the measurement of synaptic latencies and transmission velocities within a compartmentalized 3D neural tissue, utilizing localized optical stimulation and drug delivery for detailed analysis of neural circuit dynamics . This study proposed new uses of modular platforms such as in situ monitoring of various parameters in drug screening.
- Who: Yoojeong Kim from the Electrophysiological recording of organoids is crucial for assessing the functional maturity and activity of electrogenic organoids, reflecting real-time neural or cardiac responsesFor brain organoids, these measurements provide insight into neuronal network development, synaptic connectivity, and spontaneous activity patterns . . .
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