Nucleotide mismatches prevent intrinsic self-silencing of hprna transgenes to enhance rnai stability in plants

HIGHLIGHTS

• who: Daai Zhang from the University of have published the paper: Nucleotide mismatches prevent intrinsic self-silencing of hpRNA transgenes to enhance RNAi stability in plants, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that introducing nucleotide mismatches to disrupt IR DNA structure results in uniform and persistent RNAi in plants. The authors provide evidence that the IRassociated DNA methylation and self-silencing is not affected in two mutants of the RdDM pathway, and that siRNAs from G:U hpRNA transgenes are processed and function differently from traditional hpRNA transgenes, providing insights . . .
  

   

  

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