Optogenetic elevation of postsynaptic cgmp in the hippocampal dentate gyrus enhances ltp and modifies mouse behaviors

HIGHLIGHTS

• What: In all the experiments, the same objects (a cube with black dots) were used, and data for the time around each object (sec) and number of entries (based on the selected region of interest) were collected. The study was designed to determine the role of cGMP in synaptic plasticity and cognitive functions, with a specific focus on MPP fibers synapsing onto dentate gyrus (DG) granule neurons (MPP-DG synapses). The authors demonstrated that elevation of cGMP specifically within DG granule neurons is capable of enhancing LTP at MPP-DG synapses and modifying mouse behaviors.
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