HIGHLIGHTS
- who: Bernhard Ryffel from the Laboratory of Experimental and Molecular Immunology and Neurogenetics, UMR , CNRS-University of Orleans, Tokyo Medical University, Japan have published the research work: Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation, in the Journal: (JOURNAL)
- what: The authors identified an AhR ligand, the lipoxin A4, a tryptophan metabolite, which is produced after chronic exposure to ozone and induces AhR activation in the lung. Using IL-22-/-, IL-22Rα-/-, and IL-22xIL-17Rα-/- mice, the authors demonstrate the pro-inflammatory role of IL-22 during chronic ozone . . .
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