Pharmacogenetic landscape of pain management variants among mediterranean populations

HIGHLIGHTS

• What: Next, the authors evaluate the similarity of the runs at each K level with the CLUMPAK software (Kopelman et_al, 2015). The authors focused the structural analysis primarily on three nonsynonymous single nucleotide polymorphisms "nsSNPs" (rs4680, rs6267, and rs2227931). The authors employed a molecular docking approach to investigate the interaction between wild-type and mutant COMT proteins, specifically rs4680 and rs6267 variants, with dopamine. The authors investigated the pharmacogenetic landscape of variants implicated in pain management across the Mediterranean region, compared to other groups of populations.
• Who: Georgia Ragia and colleagues from the Democritus University . . .
  

   

  

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