HIGHLIGHTS
- who: Laurence H. Arnold et al. from the Institute for Human Development, Faculty of Medicine and Human Sciences, University of Manchester, Manchester, United Kingdom have published the paper: Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction, in the Journal: (JOURNAL)
- what: Based on the findings the authors propose model for phosphorylationdependent regulation of activity where dephosphorylation switches housekeeping found in cycling cells to high-activity stable tetrameric form that depletes and maintains low levels of dNTPs in differentiated cells. The authors demonstrate that both the HD domain and CtD are required for restriction . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.