Pre- and postsynaptic signatures in the prelimbic cortex associated with “alcohol use disorder” in the rat

HIGHLIGHTS

  • What: The authors aimed to define neurophysiological correlates associated with an individual`s risk of manifesting AUDlike behavior in adult rats. The authors focused on the prelimbic (PL) mPFC subregion which is thought to play a role in the manifestation of drug seeking behaviors . Using a multi-symptomatic model of addiction, the authors demonstrate that neuroadaptations in the prelimbic cortex occur exclusively in rats manifesting AUD-like traits.
  • Who: Ana Domi from the Ex vivo electrophysiology Subjects A total of , (, SA, controls) male Wistar rats (230, g) were housed in pairs under a , h reversed . . .

     

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