HIGHLIGHTS
- who: Volkhard Helms and colleagues from the Center forSaarland University have published the research: Proteomics reveals signal peptide features determining the client speci city in human TRAP-dependent ER protein import, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors propose that this SP heterogeneity may provide an opportunity for regulation of transport of a subset of precursor polypeptides and may be linked to both TRAP mechanism and CDG etiology.
- how: To validate the TRAP clients the authors conducted independent silencing experiments with TRAPB- targeting siRNAs and subjected three SP-containing candidates . . .
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