Senescence of endplate osteoclasts induces sensory innervation and spinal pain

HIGHLIGHTS

• What: The authors report that significantly increased numbers of senescent osteoclasts (SnOCs) are observed in mouse models of spinal hypersensitivity like lumbar spine instability (LSI) or aging compared to controls. The authors show that deletion of senescent cells by administration of the senolytic drug Navitoclax (ABT263) results in significantly less spinal hypersensitivity spinal degeneration porosity of the endplate sensory nerve innervation and H-type vessel growth in the endplate. The authors demonstrate the presence of SnOCs in the porous endplates in two different spinal hypersensitivity mouse models induced by aging and LSI, respectively. The authors report that . . .
  

   

  

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