Senolytic effects of exercise in human muscles require acute inflammation

HIGHLIGHTS

• What: This study was designed to investigate the causality between exercise-induced senolytic effects and inflammation using ibuprofen, a widely used anti-inflammatory drug. The authors hypothesized that the senolytic effect of exercise is AGING showed negligible changes in p16INK4a mRNA. This study provides the first evidence demonstrating the importance of acute inflammation on the senolytic effect of exercise. The authors provide the first evidence demonstrating an attenuated senolytic effect of HIIE in human skeletal AGING muscle under ibuprofen treatments, suggesting the necessity of inflammation for the exercise-induced senolytic outcomes.
• Who: AGING and colleagues . . .
  

   

  

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