Single-character insertion–deletion model preserves long indels in ancestral sequence reconstruction

HIGHLIGHTS

• What: The authors investigate the effect of the singlecharacter assumption on reconstructed sequences on protein orthologs and on simulated data. The authors show that ARPIP`s estimates preserve the observed in the input alignment. The authors focus on investigating the reconstructing power of a probabilistic model of sequence evolution that includes the insertion and deletion processes over time, which can allow the authors to compare insertion, deletion and substitution rates in more general evolutionary contexts. The aims of this study Having an explicit model of indel evolution is desirable; however, an over-simplistic model could also have . . .
  

   

  

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