HIGHLIGHTS
- who: Si-Cheng Liu from the Institute of Translational Medicine, University People`s Republic of China have published the Article: Target residence of Cas9-sgRNA influences DNA double-strand break repair pathway choices in CRISPR/Cas9 genome editing, in the Journal: (JOURNAL)
- what: The authors demonstrate that weakening target interaction of Cas9-sgRNA promotes the repair bias towards c-NHEJ at the same Cas9-induced DSBs.
SUMMARY
In CRISPR/Cas9 genome editing, targeting Cas9 to a given site is mediated by several interactions, including the contacts between Cas9 and the protospacer . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.