HIGHLIGHTS
- who: Saheli Chowdhury from the (UNIVERSITY) have published the article: Temperature-controlled Structural Alterations of an RNA Thermometer*, in the Journal: (JOURNAL) of June/27,/2003
- what: The authors show here by a series of in_vivo and in_vitro approaches that ROSE is a sensitive thermometer responding in the physiologically relevant temperature range between 30 and 40 u00b0C. Point mutations predicted to disrupt base_pairing enhanced expression at 30 u00b0C. Compensatory mutations restored repression, emphasizing the importance of secondary_structures in the sensory RNA. This study shows that expression of ROSE-containing heat shock genes is tightly controlled . . .
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