The n terminus of a schistosome ù² subunit regulates inactivation and current density of a cav2 channel*

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• who: Vicenta Salvador-Recatalà from the Vicenta Salvador-Recatalà, and Robert MGreenberg From the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania , The ␤ subunit of high voltage-activated Ca2ⴙ (Cav) channels targets the pore-forming ␣, subunit to the plasma membrane and tunes the biophysical phenotype of the Cav channel complex. We used a combination of molecular biology and wholecell patch clamp to investigate the functional role of a long, terminal polyacidic motif (NPAM) in a Cav␤ subunit of the human parasite Schistosoma mansoni (␤Sm), a motif that does not occur in other known . . .
  

   

  

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