Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs

HIGHLIGHTS

  • What: In the present study, guinea pigs were exposed intranasally to TLR agonists over four days to investigate the airway responses to a simulated microbial infection. This study showed that TLR agonists stimulation can mimic microbial infections, causing several asthmalike features, such as airway inflammation, AHR and increased mast cell numbers in guinea pigs.
  • Who: Yujiao Xiang et al. from the (UNIVERSITY) have published the Article: RESEARCH Open Access, in the Journal: (JOURNAL)
  • How: Histological and PCR data were analyzed using one-way ANOVA with Dunnett`s test to compare each group to . . .

     

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