Transcriptomic profiling of peripheral b cells in antibody positive sjogren’s patients reveals interferon signature

HIGHLIGHTS

• What: The authors aimed to analyze the transcriptome of circulating B cells from patients with SJD and healthy controls to decipher the B-cell-specific contribution to SJD. The aim of this study was to gain a better understanding of the regulatory molecular pathways in B cells. The authors performed RNA-sequencing in five well-phenotyped patients with Sjögren`s disease who had not yet received any treatment, who tested positive for SSA (both Ro60 and Ro52), SSB, and rheumatoid factor, and compared these to five age- and sex-matched normal controls.
• Who: Mehrnaz . . .
  

   

  

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