Tumor-intrinsic enhancer of zeste homolog 2 controls immune cell infiltration, tumor growth, and lung metastasis in a triple-negative breast cancer model

HIGHLIGHTS

• What: The authors report the successful CRISPR-aided generation of several EZH2 KO and EZH2 OE clones derived from the 4T1 murine TNBC cell line. Limiting TIN infiltration to enable TIL antitumor activity (i.e., making cold tumors hot) is a major goal of current research . Fifth, the study assessed tumor growth in_vivo every 3 days, but metastatic potential only at endpoint (21 or 28 days), and only in the lung.
• Who: Lenore Monterroza and collaborators from the Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA have published the research: Tumor-Intrinsic . . .
  

   

  

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