HIGHLIGHTS
- What: The authors demonstrate the meta-C-Hdifluoromethylation of pyridines through a radical process by using oxazino pyridine intermediates, which are easily accessed from pyridines.
- Who: Pengwei Xu from the (UNIVERSITY) have published the Article: (TITLE), in the Journal: (JOURNAL) of 16/02/2024
- How: The authors commenced the investigations with the difluoromethylation of the oxazino pyridine 3 and after extensive experimentation the authors found that the reaction is best conducted in acetonitrile in the presence of acetic acid (0.5 equiv.) and 2266-tetramethylpiperidine (TMP 2.5 equiv.) upon irradiation (LED 456 . . .
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