Collagen-derived dipeptide prolyl-hydroxyproline cooperates with foxg1 to activate the pgc-1α promoter and induce brown adipocyte-like phenotype in rosiglitazone-treated c3h10t1/2 cells

HIGHLIGHTS

• What: The authors investigated the effect of Pro-Hyp on the differentiation of brown adipocytes using C3H10T1/2 cells and explored its action mechanism. Pro-Hyp responsive element upstream of the PGC-1α gene in adipocytes To further elucidate the mechanism by which Pro-Hyp influences brown adipocyte differentiation, the authors focused on the -2,139 to -1946 region upstream of the PGC-1α gene, identified as the DI region containing at least two the Fox core sequence. The experiments were performed using primers specifically designed to target these sequences (as shown in Figure 5A and detailed . . .
  

   

  

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